Journal of Medicinal Chemistry
Volume 40, Issue 13 (June 20, 1997)
Copyright © 1997 American Chemical Society

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1941-1946

Pyridazinodiazepines as a High-Affinity, P2-P3 Peptidomimetic Class of Interleukin-1-Converting Enzyme Inhibitor Roland E. Dolle, C. V. C. Prasad, Catherine P. Prouty, Joseph M. Salvino, Mohamed M. A. Awad, Stanley J. Schmidt, Denton Hoyer, Tina Morgan Ross, Todd L. Graybill, Gary J. Speier, Joanne Uhl, Bruce E. Miller, Carla T. Helaszek, and Mark A. Ator [Full Article - PDF]

1947-1954

Targeting Nitric Oxide (NO) Delivery in Vivo. Design of a Liver-Selective NO Donor Prodrug That Blocks Tumor Necrosis Factor--Induced Apoptosis and Toxicity in the Liver Joseph E. Saavedra, Timothy R. Billiar, Debra L. Williams, Young-Myeong Kim, Simon C. Watkins, and Larry K. Keefer [Full Article - PDF]

1955-1968

Structure-Activity Relationships of N-Hydroxyurea 5-Lipoxygenase Inhibitors Andrew O. Stewart, Pramila A. Bhatia, Jonathan G. Martin, James B. Summers, Karen E. Rodriques, Michael B. Martin, James H. Holms, Jimmie L. Moore, Richard A. Craig, Teodozyj Kolasa, James D. Ratajczyk, Hormoz Mazdiyasni, Francis A. J. Kerdesky, Shari L. DeNinno, Robert G. Maki, Jennifer B. Bouska, Patrick R. Young, Carmine Lanni, Randy L. Bell, George W. Carter, and Clint D. W. Brooks [Full Article - PDF]

1969-1976

Zinc Ejection as a New Rationale for the Use of Cystamine and Related Disulfide-Containing Antiviral Agents in the Treatment of AIDS Nazli B. McDonnell, Roberto N. De Guzman, William G. Rice, Jim A. Turpin, and Michael F. Summers [Full Article - PDF]

1977-1981

Pyrrolomorphinans as Opioid Receptor Antagonists. The Role of Steric Hindrance in Conferring Selectivity F. Farouz-Grant and P. S. Portoghese [Full Article - PDF]

1982-1989

Probing the Active Sites of Monoamine Oxidase A and B with 1,4-Disubstituted Tetrahydropyridine Substrates and Inactivators Sonya L. Palmer, Stéphane Mabic, and Neal Castagnoli, Jr. [Full Article - PDF]

1990-2002

Conformationally Restrained Melatonin Analogues: Synthesis, Binding Affinity for the Melatonin Receptor, Evaluation of the Biological Activity, and Molecular Modeling Study Gilberto Spadoni, Cesarino Balsamini, Giuseppe Diamantini, Barbara Di Giacomo, and Giorgio Tarzia , Marco Mor, Pier Vincenzo Plazzi, and Silvia Rivara , Valeria Lucini, Romolo Nonno, Marilou Pannacci, Franco Fraschini, and Bojidar Michaylov Stankov [Full Article - PDF]

2003-2010

1-(2-Alkanamidoethyl)-6-methoxyindole Derivatives: A New Class of Potent Indole Melatonin Analogues Giorgio Tarzia, Giuseppe Diamantini, Barbara Di Giacomo, and Gilberto Spadoni , Daniele Esposti , Romolo Nonno, Valeria Lucini, Marilou Pannacci, Franco Fraschini, and Bojidar Michaylov Stankov [Full Article - PDF]

2011-2016

A New Rational Hypothesis for the Pharmacophore of the Active Metabolite of Leflunomide, a Potent Immunosuppressive Drug Giorgio Bertolini, Mario Aquino, Mauro Biffi, Gaetano d'Atri, Francesco Di Pierro, Francesco Ferrario, Paolo Mascagni, Flavio Somenzi, Andrea Zaliani, and Flavio Leoni [Full Article - PDF]

2017-2034

(2-Methyl-5-(methylsulfonyl)benzoyl)guanidine Na+/H+ Antiporter Inhibitors Manfred Baumgarth, Norbert Beier, and Rolf Gericke [Full Article - PDF]

2035-2039

Synthesis and in Vitro Evaluation of Two Progressive Series of Bifunctional Polyhydroxybenzamide Catechol-O-methyltransferase Inhibitors Sharon E. Brevitt and Eng Wui Tan [Full Article - PDF]

2040-2046

Synthesis and Antitumor Properties of N-[2-(Dimethylamino)ethyl]carboxamide Derivatives of Fused Tetracyclic Quinolines and Quinoxalines: A New Class of Putative Topoisomerase Inhibitors Leslie W. Deady, Anthony J. Kaye, Graeme J. Finlay, Bruce C. Baguley, and William A. Denny [Full Article - PDF]

2047-2052

Structure-Activity Relationship of Newly Synthesized Quinoline Derivatives for Reversal of Multidrug Resistance in Cancer Tsuneji Suzuki, Nobuyuki Fukazawa, and Kunio San-nohe , Wakao Sato and Osamu Yano , Takashi Tsuruo [Full Article - PDF]

2053-2063

8-(1H-Imidazol-1-yl)-7-nitro-4(5H)-imidazo[1,2-a]quinoxalinone and Related Compounds: Synthesis and Structure-Activity Relationships for the AMPA-type Non-NMDA Receptor Junya Ohmori, Masao Shimizu-Sasamata, Masamichi Okada, and Shuichi Sakamoto [Full Article - PDF]

2064-2084

Discovery of an Orally Active Series of Isoxazoline Glycoprotein IIb/IIIa Antagonists Chu-Biao Xue, John Wityak, Thais M. Sielecki, Donald J. Pinto, Douglas G. Batt, Gary A. Cain, Michael Sworin, Arlene L. Rockwell, John J. Roderick, Shuaige Wang, Michael J. Orwat, William E. Frietze, Lori L. Bostrom, Jie Liu, C. Anne Higley, F. Wayne Rankin, A. Ewa Tobin, George Emmett, George K. Lalka, Jean Y. Sze, Susan V. Di Meo, Shaker A. Mousa, Martin J. Thoolen, Adrienne L. Racanelli, Elizabeth A. Hausner, Thomas M. Reilly, William F. DeGrado, Ruth R. Wexler, and Richard E. Olson [Full Article - PDF]

2085-2101

Non-Peptide RGD Surrogates Which Mimic a Gly-Asp -Turn: Potent Antagonists of Platelet Glycoprotein IIb-IIIa Matthew J. Fisher, Bruce Gunn, Cathy S. Harms, Allen D. Kline, Jeffrey T. Mullaney, Anne Nunes, Robert M. Scarborough, Ann E. Arfsten, Marshall A. Skelton, Suzane L. Um, Barbara G. Utterback, and Joseph A. Jakubowski [Full Article - PDF]

2102-2106

Structure-Activity Relationships of Diverse Annonaceous Acetogenins against Multidrug Resistant Human Mammary Adenocarcinoma (MCF-7/Adr) Cells Nicholas H. Oberlies, Ching-jer Chang, and Jerry L. McLaughlin [Full Article - PDF]

2107-2107

Combinatorial Peptide and Nonpeptide Librar-ies Edited by Günther Jung. VCH Publishers, Inc., New York. 1996. xxvii + 544 pp. 17.5 × 24.5 cm. ISBN 3-527-29380-9. $170.00. Donald J. Kyle [Full Article - PDF]

2107-2108

Bacteria and Antibacterial Agents By John Mann and M. James C. Crabbe. Spektrum Academischer Verlag GmbH; copublished in the United States by University Science Books, Sausalito, CA. 1996. vii + 74 pp. 19 × 24 cm. ISBN 0-935702-91-1. $17.25. Kenneth G. Holden [Full Article - PDF]

2108-2108

Ethnobotany: Principles and Applications By C. M. Cotton. John Wiley and Sons, Ltd., Baffins Lane, Chichester, West Sussex, PO19 1UD, England. 1996. ix + 424 pp. 15 × 23.5 cm. ISBN 0-471-95537-X. $49.95 (pbk). Michael Montagne [Full Article - PDF]

2108-2109

Handbook of Essential Fatty Acid Biology. Biochemistry, Physiology, and Behavioral Neurobiology Edited by Shlomo Yehuda and David I. Mostofsky. Humana Press, Totowa, NJ. 1997. x + 470 pp. 15.5 × 23.5 cm. ISBN 0-89603-365-1. $145.00. [Full Article - PDF]

2109-2109

Molecular Diversity and Combinatorial Chemistry Edited by Irwin M. Chaiken and Kim D. Janda. American Chemical Society, Washington, DC. 1996. ix + s. 15.5 × 23.5 cm. ISBN 0-8412-3450-7. $109.95. Joseph Weinstock [Full Article - PDF]

2109-2109

Guidebook to the Calcium-Binding Proteins Edited by Marco R. Celio. Oxford University Press Inc., New York. 1996. xvi + 238 pp. 19 × 24.5 cm. ISBN 0-19-859950-1. $34.95 (pbk). Jeremy Gilmore [Full Article - PDF]

2109-2109

Saponins Used in Traditional and Modern Medicine. Volume 404 in the series Advances in Experimental Medicine and Biology Edited by George R. Waller and Kazuo Yamasaki. Plenum Press, New York. 1996. xiii + 606 pp. 17 × 25.5 cm. ISBN 0-3-6-45393-2. 145.00. Maurice Shamma [Full Article - PDF]

2109-2110

Books of Interest [Full Article - PDF]